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← Human Body & HealthA patient with autoimmune disease experiences chronic inflammation. If a therapy targeting only TNF-alpha is applied, which consequence follows?
A)Complete resolution of immune dysregulation
B)Enhanced B-cell antibody production results
C)Increased susceptibility to viral infections
D)Compensatory upregulation of other cytokines✓
💡 Explanation
Blocking TNF-alpha can trigger compensatory mechanisms, because the immune system attempts to maintain homeostasis; therefore, other pro-inflammatory cytokines may increase to offset the reduction in TNF-alpha, rather than achieving complete resolution due to redundancy in cytokine signaling.
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