A patient with impaired renal function is prescribed a medication heavily reliant on glomerular filtration. Which risk increases as filtration rate declines?

💡 Explanation

Reduced glomerular filtration impairs the clearance of the drug from the bloodstream via the nephrons. Because drug excretion is diminished, systemic drug concentration increases, leading to potential toxicity, therefore option D is correct rather than the drug being metabolized faster or being less effective.

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