A patient with rheumatoid arthritis takes a TNF-alpha inhibitor. Which consequence becomes likely due to this immunosuppression?

💡 Explanation

TNF-alpha inhibitors suppress the immune system. Because TNF-alpha is critical for containing latent tuberculosis, immunosuppression can lead to reactivation of the infection; therefore, the correct answer is reactivation of latent tuberculosis, rather than enhanced histamine response, which might occur in allergic reactions. B cell activation could also be impacted, but TB reactivation is a more direct risk.

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