An individual begins a high-fat diet. Which effect results when considering the gut-brain axis and hormone regulation of appetite?

💡 Explanation

A high-fat diet often leads to decreased secretion of glucagon-like peptide-1 (GLP-1), which normally enhances satiety. Because GLP-1 signals satiety to the brain, a reduction in GLP-1 secretion results in reduced appetite suppression; therefore, decreased GLP-1 leads to reduced appetite, rather than increased appetite or altered satiety signals from other hormones.

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