As aging progresses, why does bone fracture risk increase disproportionately compared to the overall decline in bone mineral density when subjected to impacts?

💡 Explanation

Increased bone fracture risk during aging occurs due to advanced glycation end-products (AGEs) causing collagen cross-linking, making the bone brittle and less resilient to impact because collagen provides tensile strength. Therefore, collagen damage contributes to fracture risk, rather than simply reduced bone density or changes in bone cell differentiation alone.

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