During assisted reproductive technology (ART), what causes premature luteinization of granulosa cells after FSH/LH stimulation?

💡 Explanation

Premature luteinization during ART is linked to elevated intrafollicular progesterone because excessive FSH/LH stimulation causes premature differentiation of granulosa cells. This results in early progesterone secretion, which negatively impacts oocyte quality and implantation, therefore, elevated intrafollicular progesterone is the cause rather than decreased progesterone or aromatase inhibition.

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