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← Human Body & HealthWhy does a Vitamin C deficiency lead to impaired wound healing in scurvy?
A)Increased neutrophil collagenase activity
B)Reduced angiogenesis stimulation factors
C)Excessive fibroblast proliferation inhibition
D)Decreased collagen hydroxylase activity✓
💡 Explanation
Scurvy impairs wound healing because it involves a Vitamin C deficiency, a necessary cofactor for prolyl and lysyl hydroxylases. These enzymes are vital for collagen stabilization via hydroxylation; therefore, the structural integrity of newly synthesized collagen is compromised, rather than another factor, and wound closure fails.
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