During high-altitude ascent, which consequence results when the Bohr effect and 2,3-BPG concentration synergistically increase within red blood cells to cause greater oxygen unloading at the tissues?

💡 Explanation

Increased 2,3-BPG and the Bohr effect both shift the hemoglobin saturation curve to the right. This facilitates oxygen unloading at the tissues because hemoglobin's affinity for oxygen decreases; therefore, tissue oxygen delivery increases, rather than affinity increasing or erythropoietin or chemoreceptor changes dominating.

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