During in vitro fertilization, a batch of oocytes are exposed to hyaluronidase. Which outcome affecting fertilization is most likely if hyaluronidase concentrations are too high?

💡 Explanation

Excessive hyaluronidase degrades the cumulus matrix excessively, leading to premature release of ovulated oocytes and zona pellucida hardening because the oocyte prematurely initiates cortical granule release. Therefore, zona hardening impairs sperm penetration rather than other sperm-related issues such as hyperactivation or acrosome reaction inhibition.

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