Following a snake envenomation where venom-induced consumption of complement proteins occurs, why does disseminated intravascular coagulation (DIC) risk increase?

💡 Explanation

DIC risk increases due to reduced clearance of apoptotic bodies because complement depletion impairs phagocytosis by macrophages, therefore uncleared apoptotic bodies activate coagulation pathways rather than being cleared by the immune system. Antithrombin activity would decrease in DIC.

• If a patient undergoing physical therapy reports increased pain despite tissue healing based on MRI evidence, which mechanism explains this amplified pain perception?
• During hemorrhagic shock, the kidneys increase 2,3-BPG production in red blood cells; which consequence follows in systemic oxygen transport?
• A demyelinating disease slows action potential propagation along a neuron. Which effect dominates as the internodal distance increases in these neurons?
• If a patient experiences a severe asthma exacerbation triggered by histamine release from mast cells, which consequence follows from administering a beta-2 agonist inhaler?
• Why does the influenza vaccine require annual reformulation, even with an adjuvant enhancing initial immunogenicity?
• Why does Hashimoto's thyroiditis manifest when thyroglobulin is targeted?