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Human Body & Health

Following ACL reconstruction involving knee joint allograft, which outcome indicates immune reaction?

A)Persistent joint line tenderness
B)Increased bone mineral density
C)Improved range of motion
D)Decreased inflammatory cytokine levels.

💡 Explanation

Graft rejection risk elevates post-surgery because major histocompatibility complex (MHC) mismatch, initiating an immune response. The body mounts cytotoxic T cell response that damages allograft cells; therefore, persistent joint line tenderness indicates ongoing immune-mediated inflammation rather than resolution of the condition.

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