Following lung injury from asbestos inhalation, which mechanism explains the resolution of inflammation characterized by the return to tissue homeostasis, rather than chronic fibrotic changes?

💡 Explanation

Resolution of inflammation involves specialized pro-resolving mediators like lipoxins and resolvins that actively promote the return to tissue homeostasis. These mediators downregulate pro-inflammatory cytokine production and promote macrophage efferocytosis. Therefore, lipoxin and resolvin release leads to resolution, rather than persistent inflammation or fibrosis amplified by TGF-β signaling.

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