If a burn injury compromises the skin's barrier function, which consequence follows regarding transdermal drug delivery?

💡 Explanation

Burn injury disrupts the stratum corneum, which normally limits diffusion of substances, because the skin barrier function is compromised; therefore, lipophilic drugs exhibit increased absorption due to preferential partitioning into the damaged lipid matrix, rather than decreased absorption or size independence, and inflammation modulates but doesn't halt diffusion.

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