If a burn wound induces sustained systemic inflammation and subsequent hypermetabolism, which physiological consequence becomes a limiting factor in successful wound closure?

💡 Explanation

Systemic inflammation and hypermetabolism from a severe burn injury dramatically increase the body's demand for amino acids to support immune function and gluconeogenesis; therefore, depletion of circulating amino acid pools impairs collagen synthesis and wound repair, rather than accelerating keratinocyte differentiation because it cannot be sustained.

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