If a patient's inflammatory response becomes chronically activated due to persistent allergen exposure, which consequence affecting the NF-κB signaling pathway is most likely?

💡 Explanation

Persistent allergen exposure continuously activates immune cells, which triggers chronic NF-κB activation and increased expression of pro-inflammatory mediators because the NF-κB pathway governs inflammatory gene transcription; therefore, sustained activation leads to elevated mediator production, rather than pathway downregulation.

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