If a colon cancer cell line exhibits a mutation inactivating the APC tumor suppressor gene, preventing degradation of β-catenin, which consequence follows regarding growth factor signaling?

💡 Explanation

Inactivation of APC prevents β-catenin degradation, leading to its accumulation and constitutive activation of Wnt signaling, which promotes cell proliferation. Therefore, uncontrolled cell proliferation results, rather than apoptosis or cell cycle arrest, because Wnt signaling drives growth rather than suppressing it.

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