If a COX-2 selective inhibitor is administered to a patient already experiencing severe vascular inflammation, which consequence follows concerning prostaglandin E2 (PGE2) production?

💡 Explanation

Selective COX-2 inhibitors reduce PGE2, a key pro-resolving mediator at later inflammation stages. Therefore, resolution is impaired because PGE2 promotes macrophage transition to a pro-resolving phenotype, rather than primarily affecting vasodilation or gastric protection acutely.

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