If a COX-2 selective inhibitor reduces prostaglandin synthesis within inflamed synovial tissue, which consequence follows within the affected joint under load?

💡 Explanation

Selective COX-2 inhibition decreases prostaglandin production, crucial mediators that sensitize nociceptors to pain. Because nociceptor activation is reduced, pain signaling decreases; therefore, D is correct, rather than alterations to cartilage matrix or leukocyte infiltration, which are secondary to inflammation.

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