If a dorsal horn neuron is continuously bombarded by substance P from C-fiber nociceptors, which consequence affecting descending modulation is most probable?

💡 Explanation

Sustained substance P signaling from nociceptors desensitizes the dorsal horn neurons to descending inhibitory signals by reducing the activity of inhibitory interneurons. Because these interneurons normally suppress pain signals, decreased activity amplifies the pain response; therefore, decreased inhibitory interneuron activity is correct, rather than enhanced A-beta fiber transmission which reduces pain.

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