If a drug inhibits pancreatic beta cell glucokinase in a patient with Type 2 diabetes already exhibiting insulin resistance, which consequence follows?

💡 Explanation

Inhibiting glucokinase impairs the initial step of glucose metabolism in pancreatic beta cells, because this reduces ATP production which triggers insulin release. Therefore, glucose-stimulated insulin secretion decreases, rather than increases, while GLUT4 translocation and hepatic glucose production are not directly stimulated.

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