If a drug's hepatic clearance decreases due to induced CYP450 enzyme inhibition after grapefruit juice consumption, which consequence follows for a patient taking the drug?

💡 Explanation

Increased drug plasma concentration occurs because CYP450 inhibition reduces the rate of hepatic clearance, decreasing the drug's elimination from the body. Therefore, the drug accumulates, leading to higher plasma levels, rather than being metabolized and excreted more quickly.

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