If a drug with a high volume of distribution (Vd) is administered intravenously but encounters extensive binding to plasma proteins, which consequence follows for its overall effect?

💡 Explanation

Plasma protein binding limits the amount of drug that can distribute to the tissues, therefore, even if Vd is potentially high, a lower concentration reaches the target. This occurs because only the unbound fraction of the drug is pharmacologically active, rather than the protein-bound fraction being active.

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