If a long-distance runner experiences consistently elevated cortisol levels despite adequate rest, which consequence involving endocrine feedback is most likely?

💡 Explanation

Chronically elevated cortisol acts via negative feedback on the hypothalamus, reducing CRH release, because sustained high cortisol inhibits further stimulation of the HPA axis; therefore, CRH downregulation occurs, rather than stimulation of other hormonal axes like thyroid or growth hormone.

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