If a novel influenza strain evades antibody neutralization, which consequence follows regarding CD8+ T-cell mediated immunity?

💡 Explanation

A novel influenza strain evading antibody neutralization necessitates a stronger reliance on CD8+ T-cell-mediated cytotoxicity to clear infected cells. Because this cellular immune response involves the release of inflammatory cytokines to induce cell death, a cytokine storm is more probable; therefore, a cytokine storm is likely, rather than autoimmune disease, decreased macrophage activation, or increased B-cell activity.

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