If cancer cells develop a mutation disrupting the G1 checkpoint control of receptor tyrosine kinases (RTKs), which consequence follows regarding cellular apoptosis pathways?

💡 Explanation

Cancer cells bypass normal controls via mutation; therefore, mutated RTKs cause constitutive activation of downstream signaling, leading to sustained cell proliferation and inhibiting apoptosis, because the G1 checkpoint's control is lost. Rather than responding normally to apoptotic signals, cells resist apoptosis.

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