If a patient exhibits chronic inflammation due to impaired peripheral tolerance, which mechanism affecting T regulatory (Treg) cells is most likely contributing to this outcome?

💡 Explanation

Defective IL-2 signaling impairs Treg survival and function because IL-2 is crucial for Treg homeostasis and suppressive activity, therefore reducing their ability to control autoreactive T cells. Rather than other options, dysfunctional IL-2 signaling directly affects the regulatory arm of the immune system.

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