If a patient exhibits increasing insulin resistance in peripheral tissues despite normal pancreatic beta cell function, which adaptation within muscle cells causes reduced glucose uptake?

💡 Explanation

Reduced GLUT4 transporter translocation leads to decreased glucose uptake in muscle cells. Because insulin resistance impairs the normal signaling cascade that facilitates GLUT4 movement to the cell membrane, therefore less glucose is transported inside, rather than increased phosphorylation or enzyme activity which would enhance glucose metabolism.

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