If a patient has a genetic mutation causing dysfunctional fibrinogen, which consequence follows regarding clot formation following a deep wound?

💡 Explanation

Dysfunctional fibrinogen impairs the fibrin polymerization process, because the mutation prevents the proper formation of the fibrin meshwork which stabilizes the clot. Therefore, clot stabilization is impaired, rather than acceleration of other coagulation factors, as the defect lies downstream.

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