If a patient's liver sinusoidal endothelial cells lose fenestrations following chronic alcohol abuse, which consequence follows?

💡 Explanation

The loss of fenestrations impairs the ability of hepatocytes to efficiently extract drugs and toxins from the blood because the altered permeability limits their access, thereby hindering detoxification. Therefore, detoxification is impaired, rather than enhanced function or altered protein synthesis, which depend on intact hepatocytes.

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