If a patient undergoing chemotherapy develops a non-healing skin ulcer, which mechanism primarily impedes wound closure?

💡 Explanation

Chemotherapy often suppresses cell division, which impairs keratinocyte migration across the wound bed during re-epithelialization. This reduced cell motility blocks the natural healing progression because effective wound closure depends on keratinocytes migrating to cover the damaged area, therefore slowing healing, rather than other factors such as angiogenesis or fibroblast proliferation.

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