Why does anaphylactic shock, following a bee sting in a sensitized individual, primarily result in a sharp drop in blood pressure, rather than a localized inflammatory response?

💡 Explanation

Anaphylactic shock is caused by systemic mast cell degranulation, releasing large amounts of histamine. Because histamine causes widespread vasodilation, systemic vascular resistance plummets, therefore blood pressure drops significantly, rather than just causing localized inflammation near the sting site.

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