If a patient with an autoimmune disorder experiences a cytokine storm following CAR T-cell therapy, which mechanism most directly amplifies the inflammatory response, risking multi-organ damage?

💡 Explanation

The cytokine storm's inflammatory response is amplified by a positive feedback loop from IL-6 because IL-6 promotes further cytokine release, exacerbating inflammation. Therefore, IL-6 feedback accelerates tissue damage, rather than being driven by antigen presentation, direct T-cell lysis, or the complement cascade initially.

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