If a patient with cystic fibrosis experiences excessive use of antibiotics due to recurring lung infections, which consequence becomes most likely regarding skin barrier function?

💡 Explanation

Excessive antibiotics disrupt the gut microbiome, affecting nutrient absorption needed for sebum production because gut dysbiosis impairs fatty acid metabolism; therefore altered sebum reduces the skin's protective lipid barrier, rather than increasing Langerhans cell activity or filaggrin expression which would improve barrier function.

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