Why does chronic nerve compression lead to amplified pain signals from nociceptors even after the compression is relieved?

💡 Explanation

Nociceptors exhibit increased excitability following chronic nerve compression due to changes in ion channel expression. The upregulation of Nav1.8 sodium channels causes a lower threshold for action potential firing, therefore pain signals are amplified, rather than a change in glial cell activity or opioid receptors.

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