If a researcher discovers that chronically elevated levels of TNF-alpha cause systemic insulin resistance, which consequence primarily explains this phenomenon in adipocytes?

💡 Explanation

TNF-alpha promotes insulin resistance because it induces serine phosphorylation of IRS-1, which inhibits tyrosine phosphorylation, thereby impairing insulin receptor substrate activation. Therefore, insulin signaling is disrupted, rather than enhanced, within the adipocyte, causing a reduction of glucose uptake.

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