Why does administering a drug that inhibits ACE (Angiotensin-Converting Enzyme) often lead to a decrease in blood pressure?

💡 Explanation

ACE inhibition reduces the production of angiotensin II, a potent vasoconstrictor, and decreases aldosterone secretion, leading to reduced blood volume; because of this ACE inhibition reduces vasoconstriction and blood volume, therefore blood pressure decreases, rather than increasing sodium retention or sympathetic activity.

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