If a researcher introduces a mutation disrupting IRS-1 phosphorylation in skeletal muscle cells of a patient with type 2 diabetes already exhibiting insulin resistance, which consequence follows?

💡 Explanation

Disrupting IRS-1 phosphorylation impairs the insulin signaling cascade, because IRS-1 is essential for activating downstream pathways that promote GLUT4 translocation. Therefore, glucose uptake into muscle cells will be reduced, rather than enhanced, while fatty acid oxidation changes less directly.

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