If a researcher introduces a TNF-α inhibitor to counteract inflammation at a localized injury site, which consequence is most likely?

💡 Explanation

TNF-α is a key cytokine that activates neutrophils for pathogen clearance; blocking it diminishes neutrophil activity locally because TNF-α stimulates their chemotaxis and phagocytosis. Therefore, pathogen clearance is impaired, rather than enhanced neutrophil chemotaxis continuing, or prostaglandin/COX-2 activity remaining unaffected.

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