If a stroke patient arrives at the hospital within the thrombolysis time window but experiences elevated intracranial pressure, which consequence becomes the primary concern influencing tPA administration?

💡 Explanation

Increased intracranial pressure significantly elevates the risk of hemorrhagic transformation after tPA administration because the thrombolysis mechanism breaks down clots, potentially causing bleeding into the damaged brain tissue; therefore, exacerbating hemorrhage is the primary concern, rather than vasospasm or hypoperfusion, which are secondary to the initial ischemic event.

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