If an individual's blood-brain barrier's P-glycoprotein transport activity decreases, which consequence follows regarding amyloid-beta clearance?

💡 Explanation

Reduced P-glycoprotein activity impairs the ability of the blood-brain barrier to transport amyloid-beta out of the brain via efflux transport, because the transport mechanism is compromised; therefore, the amyloid-beta concentration rises, rather than undergoing enzymatic degradation or increased phagocytosis by microglia.

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