If chemotherapy targets rapidly dividing cancer cells but also affects healthy cells, which consequence in bone marrow stem cells becomes most likely, impacting long-term bone density?

💡 Explanation

Chemotherapy induces DNA damage, especially in rapidly dividing cells. Because bone marrow stem cells are constantly dividing to replenish blood cells, they are susceptible to telomere shortening. Therefore, replicative senescence is accelerated, rather than directly affecting osteoblast differentiation or calcium absorption.

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