If insulin-stimulated glucose uptake in skeletal muscle cells is chronically impaired, which consequence follows regarding pancreatic beta cell function?

💡 Explanation

Chronic insulin resistance in skeletal muscle increases demand on pancreatic beta cells to secrete more insulin to maintain glucose homeostasis. Consequently, beta-cell hyperplasia and hypertrophy occurs via compensatory mechanisms, rather than decreased function. This happens because the cells are attempting to overcome peripheral resistance, therefore beta-cell sensitivity to somatostatin is not increased.

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