In type 2 diabetes, why does hyperglycemia persist despite elevated insulin levels following a carbohydrate-rich meal?

💡 Explanation

Hyperglycemia persists in type 2 diabetes because insulin resistance impairs the translocation of GLUT4 glucose transporters to the cell surface of muscle and adipose tissue. This limits glucose uptake, therefore, blood glucose remains elevated, rather than being taken up by cells which occurs normally with GLUT4-mediated transport.

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