What causes increased left ventricular end-diastolic pressure (LVEDP) during heart failure with preserved ejection fraction (HFpEF)?

💡 Explanation

Impaired diastolic relaxation of the myocardium increases LVEDP in HFpEF because the ventricle cannot properly fill during diastole; therefore, pressure rises within the ventricle at the end of diastole, rather than a primary issue of blood volume or sympathetic activity.

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