If a drug exhibits significant first-pass metabolism following oral administration, which consequence follows, necessitating a higher dose compared to intravenous administration?

💡 Explanation

First-pass metabolism involves drug metabolism in the liver before it reaches systemic circulation, reducing the amount of drug available in the bloodstream. Because of this hepatic processing, lower systemic bioavailability results; therefore, a higher oral dose is needed to achieve the desired therapeutic effect, rather than relying on other routes.

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