What causes long-term potentiation (LTP) at a glutamatergic synapse during associative learning?

💡 Explanation

LTP, a form of synaptic plasticity, requires co-activation of NMDA receptors by glutamate and postsynaptic depolarization because magnesium block is removed, therefore calcium influx triggers intracellular signaling cascades that strengthen the synapse, rather than inhibition or changes to sodium channels.

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