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Which consequence arises when increasing rate constants non-uniformly within a metabolic pathway?

A)Byproduct accumulation overwhelms regulatory feedback
B)Enzyme production becomes thermodynamically favoured
C)Homeostasis improves during physiological stress
D)Pathway flux linearly increases proportionally

💡 Explanation

Increased rate constants create bottleneck effects in the pathway due to *enzyme saturation*, because the faster steps produce intermediates quicker than others can process them; therefore, byproducts accumulate, triggering regulatory system overload rather than improved homeostasis.

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