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Which mechanism causes decreased protein function at high temperatures?

A)Disruption of tertiary structure
B)Increased translational frameshifting
C)Accelerated peptide bond hydrolysis
D)Enhanced ribosome binding affinity

💡 Explanation

Disruption increases at higher temperatures, causing proteins to unfold because hydrogen bonds, van der Waals forces, and hydrophobic interactions are weakened in the protein's tertiary structure. Therefore the protein loses its functional shape rather than altering its amino acid sequence upstream.

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