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← ScienceWhich consequence results when a pharmaceutical protein drug's manufacturing process fails to promote correct disulfide bonds?
A)Elevated thermal decomposition temperature
B)Increased proteolytic degradation rate✓
C)Enhanced hydrophobicity in solution
D)Reduced glycosylation site occupancy
💡 Explanation
Incorrect disulfide bonds lead to improper protein folding; therefore, the protein is more susceptible to enzymatic breakdown because the proteases can access more cleavage sites, rather than structural integrity preventing degradation.
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