Which mechanism explains why chronic alcohol consumption increases the risk of drug-induced liver damage?

💡 Explanation

Chronic alcohol consumption induces CYP450 enzymes in the liver, which increases the metabolic activation of certain drugs to toxic metabolites. This process, CYP450 enzyme induction, overwhelms the liver's detoxification capacity. Therefore, drug-induced liver damage is more likely, rather than reduced blood flow or enhanced excretion.

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